Staphylococcal Exotoxins Induce Interleukin 22 in Human Th22 Cells
نویسندگان
چکیده
منابع مشابه
Staphylococcal exotoxins induce interleukin 22 in human th22 cells.
BACKGROUND We have shown previously that T cells from atopic dermatitis (AD) patients produce more IL-22 upon staphylococcal exotoxin stimulation compared to psoriasis patients and healthy controls. The role of staphylococcal exotoxins on polarized memory T helper (Th)22 cells which are enriched in inflamed AD skin remains elusive. Our aim was to investigate IL-22 production in response to stap...
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Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to i...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 2014
ISSN: 1018-2438,1423-0097
DOI: 10.1159/000367923